I agree. There’s no point using complicated layouts if there’s no reason to do so.
It is interesting to see what effects are created by using these kinds of layouts though. With the She-Hulk page, there’s a really clean and direct line of motion from the top left panel to the splat on the bottom right, which enhances the joke.
With the ‘Flying Man’ example, it creates a sense of energy and fast-changing movement. Three panels of him flying along in the same direction would be easier to follow but more boring to read. As presented, it makes him look like he’s busily zipping about.