House to Astonish is a regular listen for me. I know they have a lot of mentions in this thread, but if you want an idea of a typical episode (which come out every three or four weeks), they run for about an hour and a half, with just the two (British) hosts recording in person (it's not one of those Skype ones).
They spend the first ~30 minutes with a wrap-up of comics news since the last episode, including a run-down of key solicitations from Previews, the next ~30 reviewing two comics, always #1 issues, and the final ~30 on their "Official Handbook of the Official Handbook of the Marvel Universe", where they pick an obscure character from the OHOTMU and try to revamp them; it's usually for comedic effect but sometimes they do come up with a decent treatment.
Oh and there are no ads, or "rude" content, fine to play at work. A bugbear? Despite repeated advice they still mispronounce Liefeld.
11 O'Clock Comics is a weekly show (and it is one of those Skype ones) with three longtime (American) pals talking comics. They cover lots of ground (eps are usually just over the 2 hour mark) and there's no focus on new releases necessarily - it's basically a case of "What have you been reading/watching?" and they go from there - this could be the latest DC crossover, manga from the 80s, a webcomic, an indie book, a horror movie from the 70s, Arrow, or a silver age reprint collection. I've been introduced by the show to a lot of things that I would otherwise not have, and for the most part the hosts' tastes are diverse enough that there's something for everyone. There's a recited ad at the start and end of each episode but it's not too obtrusive. There's lots of swearing and sexual content so not one to have playing in the background at most workplaces or near kids.
The hosts did veer into politics at some point a few years back and that left a bad taste in my mouth - I went from being a weekly listener to pretty much abandoning it for a year - I'm currently almost two years behind, but the focus on old, random work means that old episodes are still worth a listen if something in the description grabs you.