After reading that article, I believe that the premise of the Framework is bull!@@#. It is not removing their greatest regret. The Framework is AIDA playing with her toys. She hates Shield and Radcliffe but loves Fitz. May's big regret becomes Stamford,CT from Civil War and flipped her from Shield to Hydra. Daisy's regret(losing Lincoln) causes her to become Sky again and in relationship with Ward, Mac and Coulson had their spine removed so they wouldn't interfere.
I think the real Fitz will recover from being the Doctor because of the heavy distortion Aida wrote into his framework. I like the Irony of Fitz' situation. Aida falls in love with him because he is the only one nice to her but then in the Framework she removes that part of Fitz.