Emerald City Comic Con 2015 was my first comic convention and up until then I pretty much only read Marvel and Hellboy related titles. The convention really opened my eyes to how much more was out there. I asked Bendis on Tumblr how he'd start a new comic collection and he said expand your boundaries and try stuff you wouldn't usually. Ironically, as a result of taking his advice I haven't bought more than a couple Marvel books in the last two years. Here's some of the stuff I've read and loved in the meantime.
PROPHET by Brandon Graham and a bunch more people
RUMBLE John Arcudi & James Harren
AUTUMNLANDS Kurt Busiek & Benjamin Dewey (I regret trade waiting all of these)
AGE OF REPTILES Ricardo Delgado (so so cool)
MARQUIS Guy Davis (so sad he stopped drawing comics)
SPACE MULLET Daniel Warren Johnson's awesome free web comic
I've also been reading the ISLAND anthology, I really liked Simon Roy's HABITAT and there's been enough cool stuff that I haven't dropped it yet (though there've been a few things that really aren't my taste)
Some older stuff I feel stupid for not having read before:
BONE by Jeff Smith
AKIRA by Katsuhiro Otomo
KABUKI David Mack
Along with these series I recently got comiXology unlimited and have sampled a ton more Image titles. Just started reading the MASK omnibus from Dark Horse which is awesome.
Still following the Mignola books.
What most of these titles have in common (other than being creator owned) is that I've met most of the creators and they were all super supportive and have given me great constructive criticism on my own stuff.